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What is Brain Cancer?

Brain cancer occurs when abnormal cells in the brain grow uncontrollably, forming a mass or tumour that can interfere with vital brain functions such as memory, movement, speech, and vision. These tumours may originate in the brain itself (known as primary brain tumours) or spread from other parts of the body (secondary or metastatic brain tumours).

The severity and treatment of brain cancer depend on several factors, including the type, size, and location of the tumour, as well as how quickly it grows. Some tumours are slow-growing and may be benign, while others are aggressive and malignant. Early diagnosis and timely medical intervention are essential to manage symptoms, control tumour growth, and improve overall outcomes.

Types of Brain Cancers

Brain cancer includes various types of tumors that develop within the brain. Each type has unique features and may require different treatments. Here are some common types:

Gliomas

Gliomas are tumors that start in the glial cells of the brain. They can vary in their level of aggressiveness and include types like glioblastomas, astrocytomas, and oligodendrogliomas.

Meningiomas

Meningiomas develop in the meninges, the protective layers surrounding the brain and spinal cord. They are often slow-growing and can be either benign or malignant.

Pituitary Tumors

These tumors occur in the pituitary gland, which is located at the base of the brain and regulates important hormones. Pituitary tumors can affect hormone levels and cause various symptoms.

Medulloblastomas

Medulloblastomas are fast-growing tumors that typically develop in the cerebellum, the part of the brain that controls balance and coordination. These tumors are more common in children but can also occur in adults.

At s, our multidisciplinary oncology team designs treatment plans specifically for each patient to ensure the best care based on their tumor type.

Brain Cancer Causes

The exact cause of brain cancer is not fully understood, but it often involves changes in the DNA of brain cells, leading to uncontrolled growth.

Causes of Primary Brain Tumors: These tumors start within the brain itself or in nearby tissues. The primary cause is believed to be genetic mutations that occur spontaneously in brain cells, causing them to grow uncontrollably and form tumors.

Causes of Secondary Brain Tumors: These tumors occur when cancer cells from other parts of the body spread to the brain, a process known as metastasis. This can happen with various cancers, including breast, colon, kidney, lung cancer, and melanoma.

Brain Cancer Risk Factors

While the exact cause of brain cancer remains unclear, certain factors may increase the risk of developing brain tumors:

  • Age: Brain tumors can occur at any age, but certain types are more common in specific age groups. For example, medulloblastomas are more frequent in children, while gliomas are more common in adults.
  • Family History: Having a family history of brain tumors or certain genetic conditions can increase the risk. Genetic syndromes like neurofibromatosis or Li-Fraumeni syndrome are associated with a higher risk of brain cancer.
  • Radiation Exposure: Previous exposure to ionizing radiation, such as radiation therapy for other conditions, may increase the likelihood of developing brain tumors.
  • Gender: Some types of brain tumors are more common in one gender than the other. For instance, meningiomas are slightly more common in women.

It’s important for individuals with these risk factors to stay proactive by scheduling regular check-ups and consulting healthcare professionals for guidance. Being informed and seeking support can help in maintaining overall health and well-being.

Brain Cancer Symptoms

Brain cancer symptoms can vary widely depending on the tumor's size, type, and location. Common symptoms may include:

  • Headaches: Persistent or severe headaches that may worsen over time.
  • Seizures: New or unexplained seizures can be a sign of a brain tumor.
  • Cognitive or Personality Changes: Memory problems, difficulty concentrating, or mood swings.
  • Nausea and Vomiting: Especially when not related to other causes, like infection or food poisoning.
  • Weakness or Numbness: Sudden weakness or numbness in a part of the body, usually on one side.
  • Vision Problems: Blurred or double vision, or loss of peripheral vision.
  • Speech Difficulties: Trouble speaking or understanding speech.

These symptoms can also be caused by other medical conditions, so it’s important to consult a healthcare professional for an accurate diagnosis.

Brain Cancer Diagnosis

At s, we follow a comprehensive, step-by-step diagnostic approach to ensure early detection, accurate assessment, and precise treatment planning for brain tumors. Every patient is cared for by a multidisciplinary team of neurologists, neurosurgeons, oncologists, radiologists, and pathologists who collaborate closely at every stage.

Initial Consultation and Clinical Evaluation

The diagnostic journey begins with a detailed medical history and neurological examination. Our specialists evaluate symptoms such as persistent headaches, vision or speech changes, loss of coordination, or seizures. This helps determine the location and possible nature of the tumor and guides the choice of further investigations. Patients are also asked about family history, prior radiation exposure, and lifestyle factors that may influence brain health.

Advanced Imaging Studies

Imaging plays a central role in brain cancer diagnosis. At s, we use the latest neuroimaging technology for clear and accurate visualisation.

  • Magnetic Resonance Imaging (MRI): MRI is the gold standard for brain tumor detection. It provides detailed, high-resolution images of the brain’s soft tissues, helping doctors identify tumor size, shape, and location. Specialized MRI sequences such as MR Spectroscopy, Diffusion Tensor Imaging (DTI), and Functional MRI (fMRI) may be used to assess the tumor’s impact on surrounding brain areas.
  • Computed Tomography (CT) Scan: CT scans are often used in emergency situations or when MRI is not suitable. They help detect bleeding, swelling, or bone involvement associated with brain tumors.
  • Positron Emission Tomography (PET) Scan: PET scans may be combined with MRI or CT to evaluate the metabolic activity of brain tissue, helping differentiate between benign and malignant tumors or between tumor recurrence and treatment effects.

Laboratory and Genetic Testing

Blood tests may be recommended to assess overall health and detect any biochemical abnormalities. In some cases, genetic and molecular profiling of the tumor is performed to understand its specific characteristics, which helps personalise treatment and predict response to targeted therapies.

Biopsy and Histopathological Examination

If imaging suggests a tumor, a biopsy is usually the next step for confirmation.

  • In a stereotactic biopsy, a small tissue sample is taken using minimally invasive techniques guided by imaging for precision.
  • During open surgery (craniotomy), a larger sample may be taken or the entire tumor may be removed for analysis.
    The sample is then examined under a microscope by expert pathologists to determine the type, grade, and molecular markers of the tumor.

After diagnostic results are available, each case is reviewed in a multidisciplinary tumor board meeting to ensure a personalised, evidence-based treatment plan aligned with international best practices. Following this, patients and their families receive detailed counseling about the tumor type, stage, and treatment options, with our care team providing emotional support and clear guidance before therapy begins.

Brain Cancer Treatment

At s, treating brain cancer involves a carefully tailored approach, combining the latest medical advancements with compassionate care. Our treatment plan is designed based on the tumor’s type, location, and the patient’s overall health, and it may include one or more of the following:

Surgery

Surgery is often the first and most common step in treating a brain tumor. The goal is to safely remove as much of the tumor as possible (maximal safe resection) to relieve symptoms, improve function, and allow for an accurate diagnosis.

  • Craniotomy: The most common approach, involving a temporary removal of a piece of the skull to access the tumor.
  • Awake Craniotomy: Performed for tumors located near areas that control vital functions (like speech or movement). The patient is briefly woken during surgery to perform tasks, allowing the surgeon to protect critical brain tissue.
  • Minimally Invasive Techniques:
    • Endoscopic Surgery: Using thin, flexible tubes with a camera (endoscopes) through small openings (sometimes through the nose) to remove tumors near the skull base or pituitary gland.
    • MRI-Guided Laser Ablation (LITT): A minimally invasive technique that uses a laser fiber guided by MRI to heat and destroy cancer cells in hard-to-reach or recurrent tumors.

Radiation Therapy

Radiation therapy uses high-energy beams (like X-rays, gamma rays, or protons) to destroy cancer cells and shrink the tumor. It is commonly used after surgery to target any remaining cells or as a primary treatment if surgery is not an option.

  • External Beam Radiation Therapy (EBRT): A machine outside the body directs beams at the tumor site. This is often delivered in small, daily doses (fractions) over several weeks.
  • Stereotactic Radiosurgery (SRS) / Stereotactic Radiotherapy (SRT): Despite the name "surgery," this is a non-invasive, highly focused form of radiation. It delivers a high dose of radiation in a single session (SRS) or a few sessions (SRT) precisely to a small target, sparing healthy tissue.
  • Proton Therapy: Uses proton particles instead of X-rays, which may offer more control over where the radiation dose stops, potentially reducing the dose delivered to surrounding healthy brain tissue.

Medical Therapies

These treatments use drugs to kill cancer cells or stop them from growing. They are often used in combination with surgery and radiation.

Chemotherapy

Chemotherapy drugs target rapidly dividing cells, including cancer cells. They can be given orally (as a pill, like Temozolomide/TMZ) or intravenously. For aggressive tumors like Glioblastoma, chemotherapy is standardly combined with radiation therapy.

Targeted Drug Therapy

Targeted therapies focus on specific genetic or molecular changes found in the tumor cells. By blocking these specific pathways, they can stop tumor growth with potentially fewer side effects than traditional chemotherapy. Examples include drugs that:

  • Block the formation of new blood vessels that tumors need to grow (anti-angiogenic drugs).
  • Target tumors with specific gene mutations (e.g., IDH-mutated tumors).

Tumor Treating Fields (TTFields)

This FDA-approved treatment for Glioblastoma uses an innovative, non-invasive device (a wearable cap) to deliver low-intensity electrical fields. These fields disrupt the division of cancer cells, slowing the tumor's growth and spread.

Clinical Trials and Emerging Treatments

For many patients, especially those with aggressive or recurrent cancers, clinical trials offer access to the newest therapeutic approaches before they are widely available. These may include:

  • Immunotherapy: Using the patient's own immune system to recognize and attack cancer cells.
  • Next-Generation Targeted Therapies: Drugs that block even more specific molecular drivers of cancer.

At s, each treatment plan is carefully crafted to ensure the best possible outcome, focusing on both effectiveness and quality of life.

Brain Cancer Complications

At s, we understand that brain cancer and its treatment can sometimes lead to complications that affect different aspects of a patient’s health and daily life. These complications may arise from the tumor itself or as side effects of treatment. Our multidisciplinary team works closely with patients to manage and minimise these challenges. Common complications include:

  • Neurological Deficits: Depending on the tumor’s location, patients may experience difficulties with movement, speech, balance, coordination, or vision.
  • Seizures: Brain tumors can interfere with normal brain activity, leading to seizures, which often require medication for control.
  • Cognitive and Behavioral Changes: Some patients may experience memory loss, difficulty concentrating, or personality changes due to tumor effects or treatments.
  • Fatigue and Weakness: Both the disease and its treatments can cause persistent fatigue, impacting day-to-day functioning.
  • Treatment-Related Side Effects: Radiation and chemotherapy can lead to nausea, hair loss, or lowered immunity. Our specialists monitor these effects carefully and provide supportive care.

Brain Cancer Prevention

While it’s not possible to prevent brain cancer entirely, certain steps may help reduce the risk and promote overall brain health. At s, we encourage preventive measures and lifestyle choices that support long-term wellness.

  • Avoid Exposure to Radiation and Harmful Chemicals: Limit unnecessary radiation exposure to the head and avoid prolonged contact with toxic substances.
  • Maintain a Healthy Lifestyle: Regular physical activity, a balanced diet rich in fruits and vegetables, and adequate sleep can strengthen the body’s defense mechanisms.
  • Protect Against Infections: Practicing good hygiene and staying up to date with recommended vaccinations may help lower certain infection-related risks.
  • Monitor Family History: For individuals with a family history of brain tumors, regular medical check-ups and genetic counseling can aid in early detection and management.
  • Manage Environmental and Occupational Risks: People who work in environments with chemical exposure should follow safety protocols to minimize risk.

Though brain cancer cannot always be prevented, awareness, early detection, and proactive lifestyle choices can make a meaningful difference in long-term outcomes.

Frequently Asked Questions

Can brain cancer be completely cured?

The possibility of a cure depends on several factors, including the type, grade, and location of the tumor, as well as how early it is diagnosed. Some benign or low-grade tumors can be completely removed through surgery, while others may be managed long-term with advanced therapies to control growth and symptoms.

How long does brain cancer treatment usually take?

Treatment duration varies based on the type of therapy. Surgery is typically a one-time procedure followed by a recovery period, while radiation therapy may take several weeks. Chemotherapy or targeted therapies can continue for several months, depending on individual response and treatment goals.

Is brain cancer hereditary?

Most brain cancers are not inherited, but certain rare genetic conditions such as Li-Fraumeni syndrome, Turcot syndrome, or neurofibromatosis can increase the risk. Genetic counseling is recommended for families with a strong history of brain or related cancers.

How does brain cancer affect mental and emotional health?

Beyond physical symptoms, patients may experience anxiety depression, or mood changes due to the tumor’s impact on brain function or the stress of treatment. At s, psychological support and counseling are integral parts of patient care to promote emotional well-being.

Can lifestyle changes help during or after treatment?

Yes. Eating a balanced diet, staying active as tolerated, maintaining good sleep hygiene, and avoiding tobacco or alcohol can improve strength, immunity, and overall recovery. Our nutritionists and rehabilitation experts guide each patient through tailored lifestyle recommendations.

What is the recovery process like after brain surgery?

Recovery varies depending on the tumor’s location and the type of surgery. Some patients recover quickly, while others may require physiotherapy, speech therapy, or occupational therapy to regain certain functions. Continuous monitoring and follow-up visits are essential.

Are there non-surgical options for brain cancer treatment?

Yes. Not all brain tumors require surgery. In cases where surgery is risky or not possible, radiation therapy, chemotherapy, targeted drug therapy, or Tumor Treating Fields (TTFields) may be used to control tumor growth and manage symptoms effectively.

Can brain cancer return after treatment?

Unfortunately, some brain tumors can recur, even after successful treatment. Regular MRI or CT scans and follow-up appointments help detect any recurrence early so that additional therapies can be started promptly.

How do doctors determine the stage or grade of a brain tumor?

Unlike other cancers that are staged by spread, brain tumors are graded based on how abnormal the cells look under a microscope. Grade I and II are usually slower-growing, while Grade III and IV are more aggressive and require intensive treatment..

Can brain cancer affect children differently than adults?

Yes. Children often develop different types of brain tumors, such as medulloblastomas, which may respond differently to treatment. Pediatric oncologists at s use specialized protocols designed specifically for younger patients.

What are the chances of leading a normal life after brain cancer treatment?

Many patients are able to return to work, school, or their normal activities, depending on the type and extent of treatment. Rehabilitation, follow-up care, and a supportive environment greatly enhance recovery and quality of life.

How often should brain cancer survivors have follow-up checkups?

Follow-up schedules vary, but typically include MRI scans every few months initially, then less frequently over time. These visits monitor recovery, detect recurrence, and manage any long-term effects of treatment.

Are there any new treatments or research advancements for brain cancer?

Yes. Clinical trials and research in immunotherapy, gene therapy, and precision medicine are rapidly advancing. s offers access to select clinical trials, allowing patients to benefit from the latest breakthroughs in brain cancer care.